Modeling VPS13B Lipid Transport Dysfunction in Cohen Syndrome Using
Brain Organoids and Retinal Models
Awardee: Berrak Uğur, PhD
Institution: Yale University School of Medicine
Grant Amount: $120,000
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Molecular Architecture of the Human VPS13B Complex
Awardees: Muhammad Ansar, PhD and Sarah Clark, PhD
Institutions: University of Lausanne, Switzerland; Oregon State
University
Grant Amount: $80,000
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In Vivo Validation of Therapeutic Candidates and Preclinical
Efficacy Biomarkers in a Mouse Model of Cohen Syndrome
Awardees: Muhammad Ansar, PhD and Binnaz Yalcin, PhD
Institutions: University of Lausanne, Switzerland; Institut
NeuroMyoGene, INSERM U1315, Lyon, France
Grant Amount: $120,000
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Understanding the role of the lipid transport protein VPS13B in
Cohen syndrome pathogenesis
Awardee: Berrak Ugur
Institution: Yale University
Grant Amount: $98,828
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Rescue of defective lipid handling in Cohen syndrome
Awardee: Jens Luders
Institution: Institute for Research in Biomedicine (IRB Barcelona),
Spain
Grant Amount: $83,282
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Preclinical assessment of potential drug candidates in VPS13b
knockout mice for the treatment of Cohen syndrome
Awardee: Muhammad Ansar
Institution: University of Lausanne
Grant Amount: $100,474
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Membrane homeostasis as potential therapeutic angle in Cohen
Syndrome
Awardee: Jens Luders
Institution: Institute for Research in Biomedicine, Barcelona, Spain
Grant Amount: $47,161
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Determination of pathomechanisms and assessment of therapeutic
strategies for Cohen Syndrome in patient derived cells and a murine
model
Awardee: Muhammad Ansar
Institution: Jules-Gonin Eye Hospital, Ophthalmology Department of
the University of Lausanne, Lausanne, Switzerland
Grant Amount: $115,000
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Determination of the retinal functions of VPS13B using a murine
model and assessment of exon-skipping as a therapeutic strategy for
Cohen Syndrome in patient-derived cells
Awardee: Laurence Faivre
Institution: CHU Dijon Bourgogne
Award Amount: $66,560
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